Innovative insights into traumatic brain injuries: biomarkers and new pharmacological targets
S Silvestro, I Raffaele, A Quartarone… - International Journal of …, 2024 - mdpi.com
A traumatic brain injury (TBI) is a major health issue affecting many people across the world,
causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting …
causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting …
Fluid biomarkers of chronic traumatic brain injury
S Friberg, C Lindblad, FA Zeiler, H Zetterberg… - Nature Reviews …, 2024 - nature.com
Traumatic brain injury (TBI) is a leading cause of long-term disability across the world.
Evidence for the usefulness of imaging and fluid biomarkers to predict outcomes and screen …
Evidence for the usefulness of imaging and fluid biomarkers to predict outcomes and screen …
Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury
Rodent models are important research tools for studying the pathophysiology of traumatic
brain injury (TBI) and developing new therapeutic interventions for this devastating …
brain injury (TBI) and developing new therapeutic interventions for this devastating …
Levels of plasma brain‐derived tau and p‐tau181 in Alzheimer's disease and rapidly progressive dementias
F Gonzalez‐Ortiz, TK Karikari… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Rapidly progressive dementias (RPDs) are a group of neurological
disorders characterized by a rapid cognitive decline. The diagnostic value of blood‐based …
disorders characterized by a rapid cognitive decline. The diagnostic value of blood‐based …
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives
MA Olesen, F Villavicencio-Tejo… - Ageing Research …, 2024 - Elsevier
Aging presents progressive changes that increase the susceptibility of the central nervous
system (CNS) to suffer neurological disorders (NDs). Several studies have reported that an …
system (CNS) to suffer neurological disorders (NDs). Several studies have reported that an …
[HTML][HTML] Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest-a multicentre study
B Þorgeirsdóttir, T Sievert, A Lybeck, NJ Ashton… - Resuscitation, 2024 - Elsevier
Purpose We studied the promising Alzheimer biomarker plasma tau phosphorylated at
threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care …
threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care …
Plasma brain‐derived tau correlates with cerebral infarct volume
F Gonzalez‐Ortiz, L Holmegaard… - Journal of Internal …, 2024 - Wiley Online Library
Background A blood‐based biomarker that accurately reflects neuronal injury in acute
ischemic stroke could be an easily accessible and cost‐effective complement to clinical and …
ischemic stroke could be an easily accessible and cost‐effective complement to clinical and …
Association of Plasma Brain-Derived Tau With Functional Outcome After Ischemic Stroke
Objectives To investigate whether circulating acute-phase brain-derived tau (BD-tau) is
associated with functional outcome after ischemic stroke. Methods Plasma tau was …
associated with functional outcome after ischemic stroke. Methods Plasma tau was …
[HTML][HTML] Brain-derived Tau for Monitoring Brain Injury in Acute Ischemic Stroke
N Vlegels, F Gonzalez-Ortiz, NL Knuth, N Khalifeh… - medRxiv, 2023 - ncbi.nlm.nih.gov
The evolution of infarcts varies widely among patients with acute ischemic stroke (IS) and
influences treatment decisions. Neuroimaging is not applicable for frequent monitoring and …
influences treatment decisions. Neuroimaging is not applicable for frequent monitoring and …
Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study
E Payne, F Gonzales-Ortiz, K Kramer, T Payne… - medRxiv, 2024 - medrxiv.org
Objective: Current methods for early detection of hypoxic–ischemic encephalopathy (HIE)
are limited by lack of specificity, cost, and time constraints. Blood tau protein concentrations …
are limited by lack of specificity, cost, and time constraints. Blood tau protein concentrations …