Innovative insights into traumatic brain injuries: biomarkers and new pharmacological targets

S Silvestro, I Raffaele, A Quartarone… - International Journal of …, 2024 - mdpi.com
A traumatic brain injury (TBI) is a major health issue affecting many people across the world,
causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting …

Fluid biomarkers of chronic traumatic brain injury

S Friberg, C Lindblad, FA Zeiler, H Zetterberg… - Nature Reviews …, 2024 - nature.com
Traumatic brain injury (TBI) is a leading cause of long-term disability across the world.
Evidence for the usefulness of imaging and fluid biomarkers to predict outcomes and screen …

Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury

I Lisi, F Moro, E Mazzone, N Marklund, F Pischiutta… - Brain, 2024 - academic.oup.com
Rodent models are important research tools for studying the pathophysiology of traumatic
brain injury (TBI) and developing new therapeutic interventions for this devastating …

Levels of plasma brain‐derived tau and p‐tau181 in Alzheimer's disease and rapidly progressive dementias

F Gonzalez‐Ortiz, TK Karikari… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Rapidly progressive dementias (RPDs) are a group of neurological
disorders characterized by a rapid cognitive decline. The diagnostic value of blood‐based …

Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives

MA Olesen, F Villavicencio-Tejo… - Ageing Research …, 2024 - Elsevier
Aging presents progressive changes that increase the susceptibility of the central nervous
system (CNS) to suffer neurological disorders (NDs). Several studies have reported that an …

[HTML][HTML] Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest-a multicentre study

B Þorgeirsdóttir, T Sievert, A Lybeck, NJ Ashton… - Resuscitation, 2024 - Elsevier
Purpose We studied the promising Alzheimer biomarker plasma tau phosphorylated at
threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care …

Plasma brain‐derived tau correlates with cerebral infarct volume

F Gonzalez‐Ortiz, L Holmegaard… - Journal of Internal …, 2024 - Wiley Online Library
Background A blood‐based biomarker that accurately reflects neuronal injury in acute
ischemic stroke could be an easily accessible and cost‐effective complement to clinical and …

Association of Plasma Brain-Derived Tau With Functional Outcome After Ischemic Stroke

TM Stanne, F Gonzalez-Ortiz, C Brännmark, K Jood… - Neurology, 2024 - AAN Enterprises
Objectives To investigate whether circulating acute-phase brain-derived tau (BD-tau) is
associated with functional outcome after ischemic stroke. Methods Plasma tau was …

[HTML][HTML] Brain-derived Tau for Monitoring Brain Injury in Acute Ischemic Stroke

N Vlegels, F Gonzalez-Ortiz, NL Knuth, N Khalifeh… - medRxiv, 2023 - ncbi.nlm.nih.gov
The evolution of infarcts varies widely among patients with acute ischemic stroke (IS) and
influences treatment decisions. Neuroimaging is not applicable for frequent monitoring and …

Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study

E Payne, F Gonzales-Ortiz, K Kramer, T Payne… - medRxiv, 2024 - medrxiv.org
Objective: Current methods for early detection of hypoxic–ischemic encephalopathy (HIE)
are limited by lack of specificity, cost, and time constraints. Blood tau protein concentrations …