The choroid plexus in healthy and diseased brain

C Kaur, G Rathnasamy, EA Ling - Journal of Neuropathology & …, 2016 - academic.oup.com
The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells
produce the cerebrospinal fluid (CSF), which has many functions including rendering …

The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond

MW Zappaterra, MK Lehtinen - Cellular and molecular life sciences, 2012 - Springer
The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu
that regulates brain development, homeostasis, and disease. Advances in proteomics …

Endogenous microglia regulate development of embryonic cortical precursor cells

JM Antony, A Paquin, SL Nutt… - Journal of …, 2011 - Wiley Online Library
Microglia play important roles in the damaged or degenerating adult nervous system.
However, the role of microglia in embryonic brain development is still largely …

Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain

S Pan, PH Yang, D DeFreitas, S Ramagiri… - Nature …, 2023 - nature.com
Cerebrospinal fluid (CSF) is essential for the development and function of the central
nervous system (CNS). However, the brain and its interstitium have largely been thought of …

Infection and immunometabolism in the central nervous system: a possible mechanistic link between metabolic imbalance and dementia

N Shinjyo, K Kita - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Metabolic syndromes are frequently associated with dementia, suggesting that the
dysregulation of energy metabolism can increase the risk of neurodegeneration and …

Extracellular control of radial glia proliferation and scaffolding during cortical development and pathology

J Ferent, D Zaidi, F Francis - Frontiers in cell and developmental …, 2020 - frontiersin.org
During the development of the cortex, newly generated neurons migrate long-distances in
the expanding tissue to reach their final positions. Pyramidal neurons are produced from …

The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis

A Annenkov - Molecular neurobiology, 2009 - Springer
The insulin-like growth factor receptor type 1 (IGF1R) signalling pathway is activated in the
mammalian nervous system from early developmental stages. Its major effect on developing …

Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach

SA Liddelow, KM Dziegielewska, CJ Ek, MD Habgood… - PloS one, 2013 - journals.plos.org
We provide comprehensive identification of embryonic (E15) and adult rat lateral ventricular
choroid plexus transcriptome, with focus on junction-associated proteins, ionic influx …

SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

V Sepúlveda, F Maurelia, M González… - Fluids and Barriers of …, 2021 - Springer
Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces
within and around the brain and spinal cord. Cerebrospinal fluid is a dynamic signaling …

SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development

A Vera, K Stanic, H Montecinos, M Torrejon… - Frontiers in cellular …, 2013 - frontiersin.org
The central nervous system (CNS) develops from the neural tube, a hollow structure filled
with embryonic cerebrospinal fluid (eCSF) and surrounded by neuroepithelial cells. Several …