Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …

Transcription-factor-based biosensors (TFBs) are often used for metabolite detection,
adaptive evolution, and metabolic flux control. However, designing TFBs with superior …

The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

The production efficiency of microbial cell factories is sometimes limited by the lack of
effective methods to regulate multiple targets in a coordinated manner. Here taking the …

Bacillus subtilis is the most characterized gram-positive bacterium that has significant
attributes, such as growing well on cheap carbon sources, possessing clear inherited …

Dynamic regulation is an effective strategy for fine-tuning metabolic pathways in order to
maximize target product synthesis. However, achieving dynamic and autonomous up-and …

Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …

Engineering the synthesis of massive amounts of therapeutics, enzymes or commodity
chemicals can select for subpopulations of nonproducer cells, owing to metabolic burden …

The global market demand for natural astaxanthin is rapidly increasing owing to its safety,
the potential health benefits, and the diverse applications in food and pharmaceutical …

Synthetic biology aims to develop programmable tools to perform complex functions such as
redistributing metabolic flux in industrial microorganisms. However, development of protein …