Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions
ranging from cell homeostasis to cell death. Molecular actions include both inhibition and …

Tuberculosis, a major health problem in developing countries, has reemerged in recent
years in many industrialized countries. The increased susceptibility of immunocompromised …

Non-tuberculous mycobacteria (NTM) is a collective name given to a group of more than 190
species of Mycobacterium. The clinical presentation for most NTM infections is non-specific …

An IFN-gamma-inducible protein, IP-10, has previously been described to belong to a gene
family of chemotactic and mitogenic proteins, associated with inflammation and proliferation …

The effector phase of an immune response involves the secretion of protein mediators by
antigen-stimulated T lymphocytes, which serve to recruit and activate the various responsive …

In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …

This article reviews the main lines of thinking and exploration that have led to our current
conception of the role of IFN-γ in immune defense and autoimmunity. In 1965 the first report …

The interferons (IFN) are one of the body's natural defensive responses to such foreign
components as microbes, tumors, and antigens. The IFN response begins with the …

N the last ten years, an avalanche of new information has flattened much of the conceptual
framework erected in the first three decades of cytokine research. This article briefly reviews …