Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …

Ghrelin stimulates appetite, increases food intake and causes adiposity by mechanisms that
include direct actions on the brain. Previously, we showed that intracerebroventricular …

Ghrelin promotes fat accumulation, despite potent stimulation of the lipolytic hormone, GH.
The function of the major circulating isoform of ghrelin, des-octanoyl ghrelin, is unclear …

It is becoming increasingly apparent that there is a degree of neurochemical overlap
between the reward systems and those regulating energy balance. We therefore …

Ghrelin, a 28-amino acid acylated peptide predominantly produced by the stomach, displays
strong growth hormone (GH)-releasing activity mediated by the hypothalamus–pituitary GH …

Here we review recent advances that identify a role for the central ghrelin signalling system
in reward from both natural rewards (such as food) and artificial rewards (that include …

Three mouse lines with altered growth hormone (GH) signaling were used to study GH's role
in adiposity. Dwarf GH receptor knockout mice (GHR−/−) and bovine GH antagonist …

Ghrelin is an acylated peptide, whose lipid modification is essential for its biological
activities. Previous studies demonstrated that it strongly stimulates GH release and has a …