Thyroid surgery for differentiated thyroid cancer—recent advances and future directions

TS Wang, JA Sosa - Nature Reviews Endocrinology, 2018 - nature.com
Population-based studies have demonstrated that an increasing number of incidental
thyroid nodules are being identified. The corresponding increase in thyroid-based …

Cost-effectiveness of precision medicine: a scoping review

M Kasztura, A Richard, NE Bempong, D Loncar… - International journal of …, 2019 - Springer
Objectives Precision medicine (PM) aims to improve patient outcomes by stratifying or
individualizing diagnosis and treatment decisions. Previous reviews found inconclusive …

The American Association of Endocrine Surgeons guidelines for the definitive surgical management of thyroid disease in adults

KN Patel, L Yip, CC Lubitz, EG Grubbs, BS Miller… - Annals of …, 2020 - journals.lww.com
Objective: To develop evidence-based recommendations for safe, effective, and appropriate
thyroidectomy. Background: Surgical management of thyroid disease has evolved …

Thyroid nodules: Global, economic, and personal burdens

N Uppal, R Collins, B James - Frontiers in Endocrinology, 2023 - frontiersin.org
Thyroid nodules have garnered attention due to changes in population surveillance systems
and rising concerns about the associated financial burden on healthcare systems, payers …

Molecular testing versus diagnostic lobectomy in Bethesda III/IV thyroid nodules: a cost-effectiveness analysis

KJ Nicholson, MS Roberts, KL McCoy, SE Carty, L Yip - Thyroid, 2019 - liebertpub.com
Background: Molecular tests (MT) using gene expression and/or mutational analysis have
been developed to reduce the need for diagnostic surgery for indeterminate (Bethesda III/IV) …

[18F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial

EJ de Koster, LF de Geus-Oei, AH Brouwers… - European Journal of …, 2022 - Springer
Purpose To assess the impact of an [18 F] FDG-PET/CT-driven diagnostic workup to rule out
malignancy, avoid futile diagnostic surgeries, and improve patient outcomes in thyroid …

The role of molecular testing for the indeterminate thyroid FNA

ED Rossi, L Pantanowitz, WC Faquin - Genes, 2019 - mdpi.com
Thyroid nodules are common in the adult population where a majority are benign and only
4.0% to 6.5% are malignant. Fine needle aspiration (FNA) is a key method used in the early …

Thyroid nodule molecular testing: is it ready for prime time?

TM Khan, MA Zeiger - Frontiers in Endocrinology, 2020 - frontiersin.org
Cytologically indeterminate thyroid nodules remain a diagnostic and clinical challenge, and
molecular testing has been advocated and advanced as a diagnostic modality to help guide …

The effect modification of ultrasound risk classification on molecular testing in predicting the risk of malignancy in cytologically indeterminate thyroid nodules

TX Hu, DT Nguyen, M Patel, K Beckett, M Douek… - Thyroid, 2022 - liebertpub.com
Background: Thyroid nodules with indeterminate cytology are increasingly subjected to
molecular testing. We evaluated the diagnostic performances of Afirma Genomic …

A machine-learning algorithm for distinguishing malignant from benign indeterminate thyroid nodules using ultrasound radiomic features

XM Keutgen, H Li, K Memeh… - Journal of Medical …, 2022 - spiedigitallibrary.org
Background: Ultrasound (US)-guided fine needle aspiration (FNA) cytology is the gold
standard for the evaluation of thyroid nodules. However, up to 30% of FNA results are …