Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of
disability. While there continues to be expansive research in posttraumatic stress disorder …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …

Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

Developmental and epileptic encephalopathies (DEEs) are complex conditions
characterized primarily by seizures associated with neurodevelopmental and motor deficits …

Background Stress and anxiety-related behaviors are seen in many organisms. Studies
have shown that in humans and other animals, treatment with selective serotonin reuptake …

Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane,
has historically been associated with the transport of cholesterol in highly steroidogenic …

Rationale The implications of the neurosteroid 3α-hydroxy-5α-pregnan-20-one
[allopregnanolone (Allo)] in neuropsychiatric disorders have been highlighted in several …

Anxiety and anxiety-like disorders describe many mental disorders, yet fear is a common
overwhelming symptom often leading to depression. Currently two basic strategies are …