Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …

The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular
signaling hub that, like the nervous system itself, integrates internal and external cues to …

Tuberous sclerosis (also known as tuberous sclerosis complex [TSC]) is a multisystem
genetic disorder that affects almost every organ in the body. Mutations in the TSC1 or TSC2 …

Background Tuberous sclerosis complex is a genetic disorder affecting every organ system,
but disease manifestations vary significantly among affected individuals. The diverse and …

Background Angiomyolipomas are slow-growing tumours associated with constitutive
activation of mammalian target of rapamycin (mTOR), and are common in patients with …

Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a
heterogenous mix of clinical and pathologic characteristics. STS can develop from fat …

Purpose Advances in minimally invasive therapies and novel targeted chemotherapeutics
have provided a breadth of options for the management of renal masses. Management of …

Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in
treating tumors harboring alterations in the mTOR pathway. Mechanisms of resistance to …

Background Tuberous sclerosis complex is a multisystem genetic disorder with a range of
physical manifestations that require evaluation, surveillance, and management. Individuals …