Cardiotoxicity of anticancer drugs: Molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop

RM Bell, M Basalay, HE Bøtker… - Basic Research in …, 2022 - Springer
Abstract The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April
2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and …

[HTML][HTML] PHB2 ameliorates Doxorubicin-induced cardiomyopathy through interaction with NDUFV2 and restoration of mitochondrial complex I function

M Yang, M Abudureyimu, X Wang, Y Zhou, Y Zhang… - Redox biology, 2023 - Elsevier
Background Doxorubicin (DOX) is among the most widely employed antitumor agents,
although its clinical applications have been largely hindered by severe cardiotoxicity. Earlier …

Current status of experimental animal skin flap models: ischemic preconditioning and molecular factors

JH Lee, HJ You, TY Lee, HJ Kang - International journal of molecular …, 2022 - mdpi.com
Skin flaps are necessary in plastic and reconstructive surgery for the removal of skin cancer,
wounds, and ulcers. A skin flap is a portion of skin with its own blood supply that is partially …

Yellow wine polyphenolic compound protects against doxorubicin-induced cardiotoxicity by modulating the composition and metabolic function of the gut microbiota

H Lin, L Meng, Z Sun, S Sun, X Huang, N Lin… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Dietary polyphenols help to prevent cardiovascular diseases, and interactions
between polyphenols and gut microbiota are known to exist. In this study, we speculated that …

Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism

P Szczepaniak, M Siedlinski… - The Journal of …, 2022 - Am Soc Clin Investig
Cardiovascular disease is the major cause of morbidity and mortality in breast cancer
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …

Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review

FN Salloum, CG Tocchetti, P Ameri, H Ardehali… - Cardio Oncology, 2023 - jacc.org
Despite improvements in cancer survival, cancer therapy–related cardiovascular toxicity has
risen to become a prominent clinical challenge. This has led to the growth of the burgeoning …

Cardiovascular disease in adult cancer survivors: a review of current evidence, strategies for prevention and management, and future directions for cardio-oncology

J Muhandiramge, JR Zalcberg, GJ van Londen… - Current Oncology …, 2022 - Springer
Abstract Purpose of Review Cardiovascular disease is long-term complication of both
cancer and anti-cancer treatment and can have significant ramifications for health-related …

Recent advances in mitochondrial fission/fusion-targeted therapy in doxorubicin-induced cardiotoxicity

C Maneechote, SC Chattipakorn, N Chattipakorn - Pharmaceutics, 2023 - mdpi.com
Doxorubicin (DOX) has been recognized as one of the most effective chemotherapies and
extensively used in the clinical settings of human cancer. However, DOX-mediated …

Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart

SM Davidson, T Padro, S Bollini, G Vilahur… - Cardiovascular …, 2021 - academic.oup.com
We review some of the important discoveries and advances made in basic and translational
cardiac research in 2020. For example, in the field of myocardial infarction (MI), new aspects …