The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …

Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological
processes and hold great potential for therapeutic and diagnostic use. Despite significant …

Extracellular vesicles (EVs) have been established to play important roles in cell-cell
communication and shown promise as therapeutic agents. However, we still lack a basic …

Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …

Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …

Genome editing technology has emerged as a potential therapeutic tool for treating
incurable diseases. In particular, the discovery of clustered regularly interspaced short …

Highlights•EVs come in two classes: native or engineered with defined therapeutic
entity.•Advances in engineering EVs to load cargo have enhanced potency.•High-density …

Cytokine storms are a primary cause of multiple organ damage and death after severe
infections, such as SARS-CoV-2. However, current single cytokine-targeted strategies …

In addition to inhibiting persistent inflammation, phosphatase and tensin homolog deleted
from chromosome 10 (PTEN) is known as an important therapeutic target for alleviating …