In ischemic stroke, there is only one approved drug, tissue plasminogen activator, to be used
in clinical conditions for thrombolysis. New neuroprotective therapies for ischemic stroke are …

Resveratrol confers neuroprotective effects in cerebral ischemia; however, the involvement
of mitophagy in the neuroprotective function of resveratrol remains unclear. The aim of the …

Ropinirole used to treat Parkinson's disease highly targets the dopaminergic receptor D3
over the D2 receptor but although both are expressed in the kidneys the ropinirole potential …

Adenosine diphosphate ribosylation (ADP-ribosylation; ADPr), the addition of ADP-ribose
moieties onto proteins and nucleic acids, is a highly conserved modification involved in a …

Abstract Treatment of Ischemic Stroke is inordinately challenging due to its complex
aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole …

GPCRs are a class of membrane proteins that are essential to signal transduction, and this
is a vital process in many different physiologies. The significant mortality rate and …

Mitochondrial dysfunction and endoplasmic reticulum (ER) stress occur in ischemic stroke.
The disruption of these two organelles can directly lead to cell death through various …

The adverse impact of disturb mitochondrial biogenesis on early brain injury (EBI) following
subarachnoid haemorrhage (SAH) has been broadly recognized and is closely associated …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and accumulating evidence indicates that mitochondrial dysfunction is …

Ropinirole (ROP) is a dopamine agonist that can cross the blood-brain barrier (BBB), which
is crucial for drugs targeting neurological conditions like Alzheimer's disease (AD). The …