Bacterial outer membrane vesicles: from discovery to applications

MG Sartorio, EJ Pardue, MF Feldman… - Annual review of …, 2021 - annualreviews.org
Secretion of cellular components across the plasma membrane is an essential process that
enables organisms to interact with their environments. Production of extracellular vesicles in …

Outer membrane vesicles of gram-negative bacteria: an outlook on biogenesis

ED Avila-Calderón, MS Ruiz-Palma… - Frontiers in …, 2021 - frontiersin.org
Outer membrane vesicles (OMVs) from Gram-negative bacteria were first described more
than 50 years ago. However, the molecular mechanisms involved in biogenesis began to be …

Outer membrane vesicles as platform vaccine technology

L Van Der Pol, M Stork, P van der Ley - Biotechnology journal, 2015 - Wiley Online Library
Outer membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐
negative bacteria. They present a range of surface antigens in a native conformation and …

Vibrio–bivalve interactions in health and disease

D Destoumieux‐Garzón, L Canesi… - Environmental …, 2020 - Wiley Online Library
In the marine environment, bivalve mollusks constitute habitats for bacteria of the
Vibrionaceae family. Vibrios belong to the microbiota of healthy oysters and mussels, which …

Outer membrane lipid secretion and the innate immune response to gram-negative bacteria

NP Giordano, MB Cian, ZD Dalebroux - Infection and immunity, 2020 - Am Soc Microbiol
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that
consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The …

Modulation of bacterial outer membrane vesicle production by envelope structure and content

C Schwechheimer, A Kulp, MJ Kuehn - BMC microbiology, 2014 - Springer
Background Vesiculation is a ubiquitous secretion process of Gram-negative bacteria,
where outer membrane vesicles (OMVs) are small spherical particles on the order of 50 to …

Bacterial extracellular vesicles and their interplay with the immune system

E Doré, E Boilard - Pharmacology & Therapeutics, 2023 - Elsevier
The mammalian intestinal tract harbors trillions of microorganisms confined within this space
by mucosal barriers. Despite these barriers, bacterial components may still be found …

The importance of porins and β-lactamase in outer membrane vesicles on the hydrolysis of β-lactam antibiotics

SW Kim, JS Lee, SB Park, AR Lee, JW Jung… - International journal of …, 2020 - mdpi.com
Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins,
found within the outer membrane, are involved in regulating the permeability of β-lactam …

Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based

W Cai, DK Kesavan, J Wan, MH Abdelaziz, Z Su… - Diagnostic pathology, 2018 - Springer
Abstract Both Gram-Positive and Gram-Negative bacteria can secrete outer membrane
vesicles (OMVs) in their growth and metabolism process. Originally, OMVs were considered …

Engineered Outer Membrane Vesicles as Nanosized Immune Cell Engagers for Enhanced Solid Tumor Immunotherapy

J Sun, L Tan, BC Ye, X Bi - ACS nano, 2024 - ACS Publications
Although tumor immunotherapy has achieved significant success in recent years, tackling
solid tumors remains a formidable challenge. Here, we present an approach that utilizes …