Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
related proteins (CRISPR/Cas) are regarded as the next generation of molecular diagnostic …

Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …

Transition from maternal to embryonic transcriptional control is crucial for embryogenesis.
However, alternative splicing regulation during this process remains understudied. Using …

Fertility traits measured early in life define the reproductive potential of heifers. Knowledge of
genetics and biology can help devise genomic selection methods to improve heifer fertility …

With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human
embryos is now possible, providing tremendous opportunities to study gene function and …

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression after
transcription. miRNAs are present in transcriptionally quiescent full-grown oocytes and …

Follicular fluid is one source of microRNAs (miRNAs). These miRNAs originate from oocytes
and their neighboring cells. The changes in the miRNAs profile in the follicular fluid could …

The CRISPR/Cas9 genome editing tool has the potential to improve the livestock breeding
industry by allowing for the introduction of desirable traits. Although an efficient and targeted …

Bull fertility is of paramount importance in bovine industry because semen from a single bull
is used to breed several thousands of cows; however, so far, no reliable test is available for …