Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

The miRNA: a small but powerful RNA for COVID-19

S Zhang, K Amahong, X Sun, X Lian, J Liu… - Briefings in …, 2021 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …

Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection

B Banaganapalli, N Al-Rayes, ZA Awan… - Computers in Biology …, 2021 - Elsevier
Background The spread of a novel severe acute respiratory syndrome corona virus 2 (SARS-
CoV-2) has affected both the public health and the global economy. The current study was …

Viral microRNAs encoded by nucleocapsid gene of SARS-CoV-2 are detected during infection, and targeting metabolic pathways in host cells

F Meng, GKH Siu, BWY Mok, J Sun, KSC Fung… - Cells, 2021 - mdpi.com
MicroRNAs (miRNAs) are critical regulators of gene expression that may be used to identify
the pathological pathways influenced by disease and cellular interactions. Viral miRNAs (v …

SARS-CoV-2-encoded MiRNAs inhibit host type I interferon pathway and mediate allelic differential expression of susceptible gene

Y Zhu, Z Zhang, J Song, W Qian, X Gu, C Yang… - Frontiers in …, 2021 - frontiersin.org
Infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the
rapid spread of coronavirus disease 2019 (COVID-19), has generated a public health crisis …

microRNAs and inflammatory immune response in SARS-CoV-2 infection: a narrative review

B Maranini, G Ciancio, M Ferracin, R Cultrera… - Life, 2022 - mdpi.com
The current SARS-CoV-2 pandemic has emerged as an international challenge with strong
medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 …

[HTML][HTML] Deep Learning for the discovery of new pre-miRNAs: Helping the fight against COVID-19

LA Bugnon, J Raad, GA Merino, C Yones, F Ariel… - Machine Learning with …, 2021 - Elsevier
Abstract The Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has been
recently found responsible for the pandemic outbreak of a novel coronavirus disease …

Detection of SARS-CoV-2 derived small RNAs and changes in circulating small RNAs associated with COVID-19

C Grehl, C Schultheiss, K Hoffmann, M Binder… - Viruses, 2021 - mdpi.com
Cleavage of double-stranded RNA is described as an evolutionary conserved host defense
mechanism against viral infection. Small RNAs are the product and triggers of post …

In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infection

A Ahmadi, S Moradi - Scientific reports, 2021 - nature.com
COVID-19 has currently become the biggest challenge in the world. There is still no specific
medicine for COVID-19, which leaves a critical gap for the identification of new drug …

In silico analysis of genomic landscape of SARS-CoV-2 and its variant of concerns (Delta and Omicron) reveals changes in the coding potential of miRNAs and their …

S Saini, S Khurana, D Saini, S Rajput, CJ Thakur… - Gene, 2023 - Elsevier
COVID-19 related morbidities and mortalities are still continued due to the emergence of
new variants of SARS-CoV-2. In the last few years, viral miRNAs have been the centre of …