Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

C Tapeinos, M Battaglini, G Ciofani - Journal of Controlled Release, 2017 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a
category of versatile drug delivery systems that have been used in the biomedical field for> …

Endothelial dysfunction in neurodegenerative diseases

YC Fang, YC Hsieh, CJ Hu, YK Tu - International journal of molecular …, 2023 - mdpi.com
The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

Molecular dynamics simulation of the interactions between sesamol and myosin combined with spectroscopy and molecular docking studies

P Han, N An, L Yang, X Ren, S Lu, H Ji, Q Wang… - Food …, 2022 - Elsevier
In this study, the mechanism of the interactions between sesamol and myosin was explored
to confirm the potential application of sesamol in a meat protein system. A series of sesamol …

Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in …

P Ganesan, P Ramalingam… - International journal …, 2018 - Taylor & Francis
Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of
phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer …

Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases

MI Teixeira, CM Lopes, MH Amaral, PC Costa - European journal of …, 2020 - Elsevier
The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

[HTML][HTML] Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

N Singh, S Vishwas, A Kaur, H Kaur, V Kakoty… - Biomedicine & …, 2023 - Elsevier
Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as
a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain …

Role of tau in various tauopathies, treatment approaches, and emerging role of nanotechnology in neurodegenerative disorders

P Kaur, A Khera, HK Alajangi, A Sharma… - Molecular …, 2023 - Springer
A few protein kinases and phosphatases regulate tau protein phosphorylation and an
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

FD Zhu, YJ Hu, L Yu, XG Zhou, JM Wu… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …

Application of iron oxide nanoparticles in the diagnosis and treatment of neurodegenerative diseases with emphasis on Alzheimer's disease

S Luo, C Ma, MQ Zhu, WN Ju, Y Yang… - Frontiers in cellular …, 2020 - frontiersin.org
Neurodegenerative diseases are characterized by chronic progressive degeneration of the
structure and function of the nervous system, which brings an enormous burden on patients …

Sesamol attenuates amyloid peptide accumulation and cognitive deficits in APP/PS1 mice: The mediating role of the gut–brain axis

Q Liu, T Xie, Y Xi, L Li, F Mo, X Liu, Z Liu… - Journal of Agricultural …, 2021 - ACS Publications
Alzheimer's disease (AD), a neurodegenerative disease, is the leading cause of dementia.
Sesamol is a lignan extracted from sesame oil and has been found to exert neuroprotective …