One mechanism by which communication between the endoplasmic reticulum (ER) and
mitochondria is achieved is by close juxtaposition between these organelles via …

Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor
protein (APP) by γ‐secretase, via an unknown mechanism. We recently showed that …

The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD …

One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins
due to changes in proteostasis involving endoplasmic reticulum (ER) stress. To alleviate ER …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

In the last few years, increased emphasis has been devoted to understanding the
contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to …

Alzheimer disease is characterized by the accumulation of abnormally folded protein
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …

The salutary intersection of fundamental cell biology with the study of disease is well
illustrated by the emerging elucidation of neurodegenerative disorders. Novel mechanisms …

Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …