In recent years, mathematical modelling of developmental processes has earned new
respect. Not only have mathematical models been used to validate hypotheses made from …

How developmental signaling proteins traverse tissue during animal development, through
or around tightly packed cells, remains an incompletely resolved mystery. Signaling protein …

Anterior-to-posterior patterning, the process whereby our digits are differently shaped, is a
key aspect of limb development. It depends on the localized expression in posterior limb bud …

During development, secreted signaling factors, called morphogens, instruct cells to adopt
specific mature phenotypes. However, the mechanisms that morphogen systems employ to …

Turing models have been proposed to explain the emergence of digits during limb
development. However, so far the molecular components that would give rise to Turing …

Understanding the mechanisms governing and regulating the emergence of structure and
heterogeneity within cellular systems, such as the developing embryo, represents a …

Since its discovery, numerous studies have shown that the Hedgehog (Hh) signaling
pathway plays an instrumental role during diverse processes of cell differentiation and organ …

Extracellular diffusion coupled with degradation is considered a dominant mechanism
behind the establishment of morphogen gradients. However, the fundamental nature of …

Patterning and growth are linked during early development and have to be tightly controlled
to result in a functional tissue or organ. During the development of the Drosophila eye, this …

Bone integrity is maintained by a dynamic equilibrium between the activities of bone-forming
osteoblasts and bone-resorbing osteoclasts. Osteolytic lesions are a painful consequence of …