Biogenesis and regulatory roles of circular RNAs
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
LNCcation: lncRNA localization and function
MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …
phenomenon that influences numerous cellular processes. This is also evident for the large …
[HTML][HTML] Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output
Q Zhao, J Liu, H Deng, R Ma, JY Liao, H Liang, J Hu… - Cell, 2020 - cell.com
Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …
genome. However, the functions of mitochondria-located noncoding RNAs are largely …
[HTML][HTML] The biogenesis, functions, and challenges of circular RNAs
Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …
[HTML][HTML] Structure and degradation of circular RNAs regulate PKR activation in innate immunity
Circular RNAs (circRNAs) produced from back-splicing of exons of pre-mRNAs are widely
expressed, but current understanding of their functions is limited. These RNAs are stable in …
expressed, but current understanding of their functions is limited. These RNAs are stable in …
The RNA modification N6-methyladenosine as a novel regulator of the immune system
Z Shulman, N Stern-Ginossar - Nature immunology, 2020 - nature.com
Protection from harmful pathogens depends on activation of the immune system, which
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
[HTML][HTML] CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
Y Xi, Y Shen, D Wu, J Zhang, C Lin, L Wang, C Yu… - Molecular cancer, 2022 - Springer
Abstract Rationale Circular RNAs (circRNAs) have been demonstrated to contribute to
esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be …
esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be …
[HTML][HTML] CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes
Existing circular RNA (circRNA) databases have become essential for transcriptomics.
However, most are unsuitable for mining in-depth information for candidate circRNA …
However, most are unsuitable for mining in-depth information for candidate circRNA …
Circular RNA in cardiovascular disease
MA Altesha, T Ni, A Khan, K Liu… - Journal of cellular …, 2019 - Wiley Online Library
Circular RNA (circRNA) are endogenous transcripts that display differential expression
across species, developmental stages, and pathologies. Their lack of free ends confers …
across species, developmental stages, and pathologies. Their lack of free ends confers …
[HTML][HTML] The functional roles of the circRNA/Wnt axis in cancer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …