In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Transcription initiation on protein-encoding genes represents a major control point for gene
expression in eukaryotes, and is mediated by RNA polymerase II and a surprisingly complex …

Advances in structure determination of the bacterial and eukaryotic transcription machinery
have led to a marked increase in the understanding of the mechanism of transcription …

An enormous body of work generated over the past three decades has revealed that
eukaryotic gene transcription is a remarkably intricate biochemical process that is tightly …

Mammalian genes are regulated by the cooperative and synergistic actions of many
transcription factors. In this study we recapitulate this complex regulation in human cells by …

Interferon-γ (IFNγ) and tumor necrosis factor-α (TNFα) cooperate to induce the expression of
many gene products during inflammation. The present report demonstrates that a portion of …

Development of a complex eukaryote requires the differential transcription of over 50,000
genes in precise spatial and temporal patterns. One of the key problems in the gene …

Address reprint requests to: Miguel Beato, MD, Institut fur Molekularbiologie und
Tumorforschung, Philipps Universitat, Emil-Mannkopff Strasse 2, 35037 Marburg, Germany …

Cocrystal structures of wild-type TATA box-binding protein (TBP) recognizing 10 naturally
occurring TATA elements have been determined at 2.3–1.8 Å resolution, and compared with …

Progesterone is a key hormone in the endometrium that opposes estrogen-driven growth.
Insufficient progesterone will result in unopposed estrogen action that could lead to the …