A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Deep analysis of next-generation sequencing data unveils numerous small non-coding
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …

The number of studies on non-coding RNAs has increased substantially in recent years
owing to their importance in gene regulation. However, the biological functions of small …

Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps
ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have …

Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high
mortality. Methods: We conducted a comprehensive study of plasma metabolites using …

Background Ferroptosis, nonapoptotic cell death mediated by free radical reactions and
driven by the oxidative degradation of lipids, is a therapeutic target because of its role in …

Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for
decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during …

Both, DNA and RNA nucleoside modifications contribute to the complex multi-level
regulation of gene expression. Modified bases in tRNAs modulate protein translation rates in …