Interoceptive regulation of skeletal tissue homeostasis and repair

Y Xiao, C Han, Y Wang, X Zhang, R Bao, Y Li, H Chen… - Bone Research, 2023 - nature.com
Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies

KR Wong, R Mychasiuk, TJ O'Brien, SR Shultz… - Bone Research, 2020 - nature.com
Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in
soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or …

Crosstalk of brain and bone—clinical observations and their molecular bases

E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

[HTML][HTML] Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: novel insights using a clinically relevant rat model

L Pham, DK Wright, WT O'Brien, J Bain, C Huang… - Neurobiology of …, 2021 - Elsevier
A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological
conditions, however there is still much unknown about the underlying mechanisms. To …

[HTML][HTML] Relationship between heterotopic ossification and traumatic brain injury: why severe traumatic brain injury increases the risk of heterotopic ossification

H Huang, WX Cheng, YP Hu, JH Chen… - Journal of orthopaedic …, 2018 - Elsevier
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone
forms in soft tissues. HO involves many predisposing factors, including congenital and …

Clinical relevance of behavior testing in animal models of traumatic brain injury

SR Shultz, SJ McDonald, F Corrigan… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …

Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

DK Wright, RD Brady, A Kamnaksh, J Trezise, M Sun… - Scientific reports, 2019 - nature.com
A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but
repeated mTBI (RmTBI) is associated with cumulative and chronic neurological …

Long-term consequences of traumatic brain injury in bone metabolism

NM Bajwa, C Kesavan, S Mohan - Frontiers in neurology, 2018 - frontiersin.org
Traumatic brain injury (TBI) leads to long-term cognitive, behavioral, affective deficits, and
increase neurodegenerative diseases. It is only in recent years that there is growing …

Exosomes and bone disease

SK Shan, X Lin, F Li, F Xu, JY Zhong… - Current …, 2019 - ingentaconnect.com
Exosomes, which mediate cell-to-cell communications and provide a novel insight into
information exchange, have drawn increasing attention in recent years. The homeostasis of …

Macromolecular dexamethasone prodrug ameliorates neuroinflammation and prevents bone loss associated with traumatic brain injury

X Wei, G Zhao, Z Jia, Z Zhao, N Chen… - Molecular …, 2022 - ACS Publications
Traumatic brain injury (TBI) is one of the leading causes of death and disability among
children and young adults in the United States. In this manuscript, we assessed the utility of …