Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

Default mode network modulation by psychedelics: a systematic review

JJ Gattuso, D Perkins, S Ruffell… - International Journal …, 2023 - academic.oup.com
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well
as profound psychological and mystical experiences. A grouping of interconnected brain …

Psilocybin desynchronizes the human brain

JS Siegel, S Subramanian, D Perry, BP Kay… - Nature, 2024 - nature.com
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Human brain effects of DMT assessed via EEG-fMRI

C Timmermann, L Roseman… - Proceedings of the …, 2023 - National Acad Sciences
Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

MK Doss, M Považan, MD Rosenberg… - Translational …, 2021 - nature.com
Psilocybin has shown promise for the treatment of mood disorders, which are often
accompanied by cognitive dysfunction including cognitive rigidity. Recent studies have …

Models of psychedelic drug action: modulation of cortical-subcortical circuits

MK Doss, MB Madden, A Gaddis, MB Nebel… - Brain, 2022 - academic.oup.com
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function

MW Johnson, PS Hendricks, FS Barrett… - Pharmacology & …, 2019 - Elsevier
The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …

Hallucinogens in mental health: preclinical and clinical studies on LSD, psilocybin, MDMA, and ketamine

D De Gregorio, A Aguilar-Valles, KH Preller… - Journal of …, 2021 - Soc Neuroscience
A revamped interest in the study of hallucinogens has recently emerged, especially with
regard to their potential application in the treatment of psychiatric disorders. In the last …

[HTML][HTML] Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

RL Carhart-Harris, L Roseman, M Bolstridge… - Scientific reports, 2017 - nature.com
Psilocybin with psychological support is showing promise as a treatment model in psychiatry
but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and …

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

F Palhano-Fontes, D Barreto, H Onias… - Psychological …, 2019 - cambridge.org
BackgroundRecent open-label trials show that psychedelics, such as ayahuasca, hold
promise as fast-onset antidepressants in treatment-resistant depression. MethodsTo test the …