Hepatitis C virus infection

MP Manns, M Buti, ED Gane, JM Pawlotsky… - Nature reviews Disease …, 2017 - nature.com
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …

[PDF][PDF] Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource

DB Smith, J Bukh, C Kuiken, AS Muerhoff… - …, 2014 - Wiley Online Library
The 2005 consensus proposal for the classification of hepatitis C virus (HCV) presented an
agreed and uniform nomenclature for HCV variants and the criteria for their assignment into …

Detection of zoonotic pathogens and characterization of novel viruses carried by commensal Rattus norvegicus in New York City

C Firth, M Bhat, MA Firth, SH Williams, MJ Frye… - MBio, 2014 - Am Soc Microbiol
Norway rats (Rattus norvegicus) are globally distributed and concentrate in urban
environments, where they live and feed in closer proximity to human populations than most …

Virome capture sequencing enables sensitive viral diagnosis and comprehensive virome analysis

T Briese, A Kapoor, N Mishra, K Jain, A Kumar… - MBio, 2015 - Am Soc Microbiol
Insensitivity and technical complexity have impeded the implementation of high-throughput
nucleic acid sequencing in differential diagnosis of viral infections in clinical laboratories …

[HTML][HTML] Virology and cell biology of the hepatitis C virus life cycle–An update

J Dubuisson, FL Cosset - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

Hepatitis C virus E2 envelope glycoprotein core structure

L Kong, E Giang, T Nieusma, RU Kadam, KE Cogburn… - Science, 2013 - science.org
Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and
hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry …

Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

DB Smith, P Becher, J Bukh… - Journal of General …, 2016 - microbiologyresearch.org
Proposals are described for the assignment of recently reported viruses, infecting rodents,
bats and other mammalian species, to new species within the Hepacivirus and Pegivirus …

[HTML][HTML] Viral pathogen discovery

CY Chiu - Current opinion in microbiology, 2013 - Elsevier
Highlights•Pathogen discovery is critically important to infectious diseases and public
health.•Nearly all new outbreaks are caused by the emergence of novel viruses.•Genomic …

Analyses of evolutionary dynamics in viruses are hindered by a time-dependent bias in rate estimates

S Duchêne, EC Holmes… - Proceedings of the …, 2014 - royalsocietypublishing.org
Time-scales of viral evolution and emergence have been studied widely, but are often poorly
understood. Molecular analyses of viral evolutionary time-scales generally rely on estimates …