Sequence similarity search programs are versatile tools for the molecular biologist,
frequently able to identify possible DNA coding regions and to provide clues to gene and …

A new approach to rapid sequence comparison, basic local alignment search tool (BLAST),
directly approximates alignments that optimize a measure of local similarity, the maximal …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

This book is concerned with the study of the probabilities of very rare events. To understand
why rare events are important at all, one only has to think of a lottery to be convinced that …

Score-based measures of molecular-sequence features provide versatile aids for the study
of proteins and DNA. They are used by many sequence data base search programs, as well …

Statistical tests for detecting mosaic structure or recombination among nucleotide
sequences usually rely on identifying a pattern or a signal that would be unlikely to appear …

Protein sequence alignments have become an important tool for molecular biologists. Local
alignments are frequently constructed with the aid of a “substitution score matrix” that …

Protein sequence alignments generally are constructed with the aid of a “substitution matrix”
that specifies a score for aligning each pair of amino acids. Assuming a simple random …

Abstract Let [0, T 1]×[0, T 2] be a rectangular region. Let hi= T i/N i> 0, where N i are positive
integers, i= 1, 2. In many applications the exact locations of the observed events in the …

Protein database searches frequently can reveal biologically significant sequence
relationships useful in understanding structure and function. Weak but meaningful sequence …