Metagenome analysis using the Kraken software suite

J Lu, N Rincon, DE Wood, FP Breitwieser… - Nature protocols, 2022 - nature.com
Metagenomic experiments expose the wide range of microscopic organisms in any
microbial environment through high-throughput DNA sequencing. The computational …

TBtools-II: A “one for all, all for one” bioinformatics platform for biological big-data mining

C Chen, Y Wu, J Li, X Wang, Z Zeng, J Xu, Y Liu… - Molecular plant, 2023 - cell.com
Since the official release of the stand-alone bioinformatics toolkit TBtools in 2020, its
superior functionality in data analysis has been demonstrated by its widespread adoption by …

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

AP Patel, M Wang, Y Ruan, S Koyama, SL Clarke… - Nature Medicine, 2023 - nature.com
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …

The complete sequence of a human Y chromosome

A Rhie, S Nurk, M Cechova, SJ Hoyt, DJ Taylor… - Nature, 2023 - nature.com
The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium

I De Baetselier, C Van Dijck, C Kenyon, J Coppens… - Nature medicine, 2022 - nature.com
The magnitude of the 2022 multi-country monkeypox virus (MPXV) outbreak has surpassed
any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed …

A draft human pangenome reference

WW Liao, M Asri, J Ebler, D Doerr, M Haukness… - Nature, 2023 - nature.com
Abstract Here the Human Pangenome Reference Consortium presents a first draft of the
human pangenome reference. The pangenome contains 47 phased, diploid assemblies …

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

R Suzuki, D Yamasoba, I Kimura, L Wang, M Kishimoto… - Nature, 2022 - nature.com
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern. In
this study, our statistical modelling suggests that Omicron has spread more rapidly than the …

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

A Saito, T Irie, R Suzuki, T Maemura, H Nasser, K Uriu… - Nature, 2022 - nature.com
During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations
have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 …

Genome-edited powdery mildew resistance in wheat without growth penalties

S Li, D Lin, Y Zhang, M Deng, Y Chen, B Lv, B Li, Y Lei… - Nature, 2022 - nature.com
Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring
disease resistance,. However, S genes are implicated in many essential biological functions …

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

V Moiseeva, A Cisneros, V Sica, O Deryagin, Y Lai… - Nature, 2023 - nature.com
Tissue regeneration requires coordination between resident stem cells and local niche
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …