The mucus layer covering the gastrointestinal (GI) tract plays a critical role in maintaining gut
homeostasis. In the colon, the inner mucus layer ensures commensal microbes are kept at a …

Microorganisms colonize the human body. The lungs and respiratory tract, previously
believed to be sterile, harbor diverse microbial communities and the genomes of bacteria …

The interaction between the microbial communities in the human body and the onset and
progression of cancer has not been investigated until recently. The vast majority of the …

Background The lymphatic contribution to the circulation is of paramount importance in
regulating fluid homeostasis, immune cell trafficking/activation and lipid metabolism. In …

Extensive research has explored the role of gut microbiota in colorectal cancer (CRC).
Nonetheless, metatranscriptomic studies investigating the in situ functional implications of …

The application of bacterial metagenomic analysis as a biomarker for cancer detection is
emerging. Our aim was to discover gut microbiota signatures with potential utility in the …

Background The association between microbes and cancer has been reported repeatedly;
however, it is not clear if molecular tumour properties are connected to specific microbial …

Microbes play important roles in human health and disease. Immunocompromised cancer
patients are more vulnerable to getting microbial infections. Regions of hypoxia and acidic …

The laboratory rat emerges as a useful tool for studying the interaction between the host and
its microbiome. To advance principles relevant to the human microbiome, we systematically …

How the gut microbiome is altered in patients with bowel polyps and contributes to polyp
progression is poorly understood. This thesis investigated the microbiome in early bowel …