Gut microbiome, liver immunology, and liver diseases

R Wang, R Tang, B Li, X Ma, B Schnabl… - Cellular & molecular …, 2021 - nature.com
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …

Immunology and immunotherapy of cholangiocarcinoma

TF Greten, R Schwabe, N Bardeesy, L Ma… - Nature Reviews …, 2023 - nature.com
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma

CL Bowlus, L Arrivé, A Bergquist, M Deneau… - Hepatology, 2023 - journals.lww.com
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

Quantitative microbiome profiling links gut community variation to microbial load

D Vandeputte, G Kathagen, K D'hoe, S Vieira-Silva… - Nature, 2017 - nature.com
Current sequencing-based analyses of faecal microbiota quantify microbial taxa and
metabolic pathways as fractions of the sample sequence library generated by each …

Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma

Q Zhang, C Ma, Y Duan, B Heinrich, U Rosato… - Cancer discovery, 2021 - AACR
Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal
disorders; however, its effect on antitumor immunity in the liver is largely unknown. Here we …

[HTML][HTML] Primary sclerosing cholangitis–a comprehensive review

TH Karlsen, T Folseraas, D Thorburn, M Vesterhus - Journal of hepatology, 2017 - Elsevier
Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

[HTML][HTML] Prognostic factors for advanced colorectal neoplasia in inflammatory bowel disease: systematic review and meta-analysis

AM Wijnands, ME de Jong, MWMD Lutgens… - Gastroenterology, 2021 - Elsevier
Background and Aims Patients with inflammatory bowel disease (IBD) have an increased
risk of colorectal cancer (CRC). We performed a systematic review and meta-analysis to …

Primary sclerosing cholangitis

JK Dyson, U Beuers, DEJ Jones, AW Lohse, M Hudson - The Lancet, 2018 - thelancet.com
Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterised by
intrahepatic or extrahepatic stricturing, or both, with bile duct fibrosis. Inflammation and …

[HTML][HTML] Optimizing methods and dodging pitfalls in microbiome research

D Kim, CE Hofstaedter, C Zhao, L Mattei, C Tanes… - Microbiome, 2017 - Springer
Research on the human microbiome has yielded numerous insights into health and disease,
but also has resulted in a wealth of experimental artifacts. Here, we present suggestions for …

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

R Tang, Y Wei, Y Li, W Chen, H Chen, Q Wang, F Yang… - Gut, 2018 - gut.bmj.com
Objective A close relationship between gut microbiota and some chronic liver disorders has
recently been described. Herein, we systematically performed a comparative analysis of the …