Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …

Mortality rates on the liver transplant waiting list are increasing. 1 The shortage of organs
has resulted in higher utilization of extended criteria donors (ECDs), with centers pushing …

Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

In vitro models serve as a tool for studies of steatosis. Palmitic and oleic acids can induce
steatosis in cultured hepatocytes. The aim of our study was to verify steatogenic and …

Mitochondrial DNA (mtDNA) copy number plays a key role in the pathophysiology of
metabolic syndrome‐related phenotypes, but its role in non‐alcoholic fatty liver disease …

The ideal deceased donor liver, a whole liver from a brain dead donor less than 40 years of
age who died of trauma, is well defined. The standard graft and the expanded liver graft are …

Liver transplantation is the most effective treatment for end-stage liver disease. Transplant
indications have been progressively increasing, with a huge discrepancy between the …

Background Severe liver steatosis is a known risk factor for increased ischemia-reperfusion
injury (IRI) and poor outcomes after liver transplantation (LT). This study aimed to identify …

Mounting evidence supports the benefits of machine perfusion for preservation of liver grafts.
Thus, machine perfusion is a promising strategy to expand the donor pool by reconditioning …

Macrovesicular steatosis in greater than 30% of hepatocytes is a significant risk factor for
primary graft nonfunction due to increased sensitivity to ischemia reperfusion (I/R) injury …