Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Copper is an essential micronutrient for both pathogens and the animal hosts they infect.
However, copper can also be toxic in cells due to its redox properties and ability to disrupt …

The importance of the Basidiomycete Cryptococcus neoformans to human health has
stimulated its development as an experimental model for both basic physiology and …

Copper (Cu) is an essential metal that is toxic at high concentrations. Thus, pathogens often
rely on host Cu for growth, but host cells can hyperaccumulate Cu to exert antimicrobial …

Copper is both an essential nutrient and potentially toxic metal, and during infection the host
can exploit Cu in the control of pathogen growth. Here we describe a clever adaptation to Cu …

The Fenton-chemistry-generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …

Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …

The pathogenic yeast Cryptococcus neoformans produces polyploid titan cells in response
to the host lung environment that are critical for host adaptation and subsequent disease …

The outbreak of fungal meningitis associated with contaminated methylprednisolone acetate
has thrust the importance of fungal infections into the public consciousness. The …