Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

Conspectus In organic synthesis, ligand-modified copper (I) hydride (CuH) complexes have
become well-known reagents and catalysts for selective reduction, particularly toward …

Hydrometallation of alkenes and alkynes provides a straightforward route to access alkyl‐or
alkenyl‐metal reagents, which have a wide range of applications in organic transformations …

Cross-coupling of two alkyl fragments is an efficient method to produce organic molecules
rich in sp 3-hybridized carbon centres, which are attractive candidate compounds in drug …

The copper-catalyzed functionalization of enyne derivatives has recently emerged as a
powerful approach in contemporary synthesis. Enynes are versatile and readily accessible …

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and
amines are of foundational importance to the practice of organic synthesis. After placing this …

In recent years, earth-abundant transition metal catalysts have been used to make great
achievements on homogenous catalysis, including the field of enantioselective …

Chiral tertiary alcohols are important building blocks for the synthesis of pharmaceutical
agents and biologically active natural products. The addition of carbon nucleophiles to …

Reported herein is a modular, NiH-catalyzed system capable of proximal-selective
hydroamination of unactivated alkenes with diverse amine sources. The key to the …

Abstract α-Branched amines are present in hundreds of pharmaceutical agents and clinical
candidates and are important targets for synthesis. Here, we show the convergent synthesis …