Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous
vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially …

Traditional medicine has provided a basis for health care and disease treatment to Chinese
people for millennia, and herbal medicines are regulated as drug products in China …

Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible
for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil …

The history of drug metabolism began in the 19th Century and developed slowly. In the mid-
20th Century the relationship between drug metabolism and toxicity became appreciated …

Citrus grandis Osbeck, commonly known as “pomelo” or “shaddock,” is the largest citrus fruit,
the peel of which is a well‐known agricultural residual waste. Pomelo peel offers a wide …

Differences in drug responsiveness are common, often leading to challenges in optimizing
the dosage regimen for a particular patient. Recent advances provide a rational framework …

Purpose Romidepsin (depsipeptide or FK228) is a member of a new class of antineoplastic
agents active in T-cell lymphoma, the histone deacetylase inhibitors. On the basis of …

Epidemiologic data support the association between high intake of vegetables and fruits and
low risk of chronic disease. There are several biologically plausible reasons why …

The delivery of drugs to a target site frequently involves crossing biological barriers. The
degree and nature of the impediment to flux, as well as the potential approaches to …

Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …