The voltage-gated sodium channel 1.5 (Nav1. 5), encoded by the SCN5A gene, is
responsible for the rising phase of the action potential of cardiomyocytes. The sodium …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Aims The prognostic value of genetic variants for predicting lethal arrhythmic events (LAEs)
in Brugada syndrome (BrS) remains controversial. We investigated whether the functional …

Since the early 1990s, the concept of primary “inherited” arrhythmia syndromes or ion
channelopathies has evolved rapidly as a result of revolutionary progresses made in …

Sudden cardiac death (SCD) accounts for approximately 15%–20% of all deaths worldwide,
the causes of which are mainly structural heart diseases. However, SCD also occurs in …

Brugada syndrome is an inherited cardiac condition with the potential for development of life-
threatening arrhythmias in relatively young individuals without significant structural cardiac …

Aim: Conventional experimental approaches used for the evaluation of the proarrhythmic
potential of compounds in the drug discovery process are expensive and time consuming …

Background Telethonin (TCAP) is a Z‐disk protein that maintains cytoskeletal integrity and
various signaling pathways in cardiomyocytes. TCAP is shown to modulate α‐subunit of the …

目的探讨Brugada 综合征SCN5A 基因新突变G1712C 的电生理机制. 方法采用体外定点诱变法
构建携带有基因突变G1712C 的pRc/CMV-hH1 的表达载体, lipo3000 脂质转染法建立稳定表达 …

Objective To elucidate the molecular and electrophysiological mechanisms of Brugada
syndrome through functional analysis of a novel SCN5A gene mutation G1712C. Methods A …