Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies
including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases …

How mitochondrial DNA mutations clonally expand in an individual cell is a question that
has perplexed mitochondrial biologists for decades. A growing body of literature indicates …

DNA transfer from cytoplasmic organelles to the cell nucleus is a legacy of the
endosymbiotic event—the majority of nuclear-mitochondrial segments (NUMTs) are thought …

Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and
drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and …

Because of their high-energy metabolism, neurons are strictly dependent on mitochondria,
which generate cellular ATP through oxidative phosphorylation. The mitochondrial genome …

Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for
synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA …

Mitochondria are subject to continuous oxidative stress stimuli that, over time, can impair
their genome and lead to several pathologies, like retinal degenerations. Our main purpose …

Mitochondrial DNA (mtDNA) mutations are a common cause of primary mitochondrial
disorders and have also been implicated in a broad collection of conditions, including aging …

Mitochondrial DNA (mtDNA) deletion syndromes predominantly comprise three overlapping
phenotypes that are usually simplex (ie, a single occurrence in a family), but rarely may be …

The development of next generation sequencing (NGS) has greatly enhanced the diagnosis
of mitochondrial disorders, with a systematic analysis of the whole mitochondrial DNA …