Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are
common in aging humans. One expected consequence of mutation-associated clonal …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …

Several bacterial fermentation products and their synthetic derivatives display antitumour
activities and bind tightly to components of the spliceosome, which is the complex molecular …

Cancer is a genetic disease, but two patients rarely have identical genotypes. Similarly,
patients differ in their clinicopathological parameters, but how genotypic and phenotypic …

Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk
of progression to acute myeloid leukemia (AML). The mechanisms of transformation of MDS …

Myelodysplastic syndrome (MDS) is clonal disorder characterized by ineffective
hematopoiesis and a tendency to evolve into acute myeloid leukemia (AML). Genetic studies …

Chromosomal deletions associated with human diseases, such as cancer, are common, but
synteny issues complicate modeling of these deletions in mice. We use cellular …

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is
associated with increased risks of hematological malignancies. While TP53 mutations have …