The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases
Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …
diseases, and achieve increased longevity. Unfortunately, increased longevity is …
Human Hsp70 disaggregase reverses Parkinson's-linked α-synuclein amyloid fibrils
X Gao, M Carroni, C Nussbaum-Krammer, A Mogk… - Molecular cell, 2015 - cell.com
Intracellular amyloid fibrils linked to neurodegenerative disease typically accumulate in an
age-related manner, suggesting inherent cellular capacity for counteracting amyloid …
age-related manner, suggesting inherent cellular capacity for counteracting amyloid …
Cellular strategies of protein quality control
B Chen, M Retzlaff, T Roos… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Eukaryotic cells must contend with a continuous stream of misfolded proteins that
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …
Aging as an event of proteostasis collapse
Aging cells accumulate damaged and misfolded proteins through a functional decline in
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …
The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system
J Shorter - PloS one, 2011 - journals.plos.org
Bacteria, fungi, protozoa, chromista and plants all harbor homologues of Hsp104, a AAA+
ATPase that collaborates with Hsp70 and Hsp40 to promote protein disaggregation and …
ATPase that collaborates with Hsp70 and Hsp40 to promote protein disaggregation and …
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
H Rampelt, J Kirstein‐Miles, NB Nillegoda, K Chi… - The EMBO …, 2012 - embopress.org
Accumulation of aggregation‐prone misfolded proteins disrupts normal cellular function and
promotes ageing and disease. Bacteria, fungi and plants counteract this by solubilizing and …
promotes ageing and disease. Bacteria, fungi and plants counteract this by solubilizing and …
Protein rescue from aggregates by powerful molecular chaperone machines
SM Doyle, O Genest, S Wickner - Nature reviews Molecular cell biology, 2013 - nature.com
Protein quality control within the cell requires the interplay of many molecular chaperones
and proteases. When this quality control system is disrupted, polypeptides follow pathways …
and proteases. When this quality control system is disrupted, polypeptides follow pathways …
Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans
ML Duennwald, AL Echeverria, J Shorter - PLoS biology, 2012 - journals.plos.org
How small heat shock proteins (sHsps) might empower proteostasis networks to control
beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that …
beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that …
[HTML][HTML] Cellular strategies for regulating functional and nonfunctional protein aggregation
J Gsponer, MM Babu - Cell reports, 2012 - cell.com
Growing evidence suggests that aggregation-prone proteins are both harmful and functional
for a cell. How do cellular systems balance the detrimental and beneficial effect of protein …
for a cell. How do cellular systems balance the detrimental and beneficial effect of protein …