Chikungunya fever

K Bartholomeeusen, M Daniel, DA LaBeaud… - Nature Reviews …, 2023 - nature.com
Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …

Rheumatic manifestations of chikungunya: emerging concepts and interventions

A Suhrbier - Nature Reviews Rheumatology, 2019 - nature.com
The largest epidemic ever recorded for chikungunya, a disease caused by infection with the
chikungunya virus (CHIKV), began in Africa in 2004 and spread to> 100 countries on four …

Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial

M Schneider, M Narciso-Abraham, S Hadl, R McMahon… - The Lancet, 2023 - thelancet.com
Background VLA1553 is a live-attenuated vaccine candidate for active immunisation and
prevention of disease caused by chikungunya virus. We report safety and immunogenicity …

COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike protein induce robust T-and B-cell immune responses and …

J García-Arriaza, U Garaigorta, P Pérez… - Journal of …, 2021 - Am Soc Microbiol
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, are urgently …

A molecular understanding of alphavirus entry and antibody protection

AS Kim, MS Diamond - Nature Reviews Microbiology, 2023 - nature.com
Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human
infection and disease on a global scale. These viruses are classified as either arthritogenic …

Vaccine and therapeutic options to control chikungunya virus

AM Powers - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Beginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …

Self-amplifying RNA vaccine candidates: alternative platforms for mRNA vaccine development

C Schmidt, BS Schnierle - Pathogens, 2023 - mdpi.com
The present use of mRNA vaccines against COVID-19 has shown for the first time the
potential of mRNA vaccines for infectious diseases. Here we will summarize the current …

A single dose of ChAdOx1 Chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial

PM Folegatti, K Harrison, L Preciado-Llanes… - Nature …, 2021 - nature.com
Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that causes swift
outbreaks. Major concerns are the persistent and disabling polyarthralgia in infected …

Single-shot live-attenuated chikungunya vaccine in healthy adults: a phase 1, randomised controlled trial

N Wressnigg, R Hochreiter, O Zoihsl… - The Lancet Infectious …, 2020 - thelancet.com
Background Chikungunya disease, which results in incapacitating arthralgia, has been
reported worldwide. We developed a live-attenuated chikungunya virus (CHIKV) vaccine …

Cellular and molecular immune response to chikungunya virus infection

ISB Tanabe, ELL Tanabe, EC Santos… - Frontiers in cellular …, 2018 - frontiersin.org
Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a
disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the …