During the past decades, remarkable progress has been made in our understanding of the
molecular basis of kidney diseases, as well as in the ability to pinpoint disease-causing …

The prevalence of renal diseases is emerging as a public health problem. Despite major
progress in supportive therapy, mortality rates among patients remain high. In an attempt to …

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal
cells have a pronounced ability to proliferate after injury, which undermines that the kidney …

Significant progress has been made to advance stem cell products as potential therapies for
kidney diseases: various kinds of stem cells can restore renal function in preclinical models …

The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that
could replenish functional homeostasis similarly to, eg, skin or the hematopoietic system …

End-stage renal disease is a worldwide epidemic requiring renal replacement therapy.
Harvesting tissue from failing kidneys and autotransplantation of tissue progenitors could …

The circadian clock genes are known important for kidney development, maturation and
physiological functions. However, whether and how they play a role in renal regeneration …

Introduction Congenital anomalies of the kidney and urinary tract (CAKUT) are the most
common kidney diseases in childhood. Alterations in genes governing nephrogenesis may …

Background Acute kidney injury (AKI) is a serious condition associated with chronic kidney
disease, dialysis requirement and a high risk of death. However, there are specialized repair …

Background Cell-based therapies aimed at replenishing renal parenchyma have been
proposed as an approach for treating CKD. However, pathogenic mechanisms involved in …