RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop.
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

Strand selection is a critical step in microRNA (miRNA) biogenesis. Although the dominant
strand may change depending on cellular contexts, the molecular mechanism and …

Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized
translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a …

During the maternal-to-zygotic transition (MZT), maternal RNAs are actively degraded and
replaced by newly synthesized zygotic transcripts in a highly coordinated manner. However …

As the building blocks of chromatin, histones are central to establish and maintain particular
chromatin states associated with given cell fates. Importantly, histones exist as distinct …

TENTs generate miRNA isoforms by 3'tailing. However, little is known about how tailing
regulates miRNA function. Here, we generate isogenic HEK293T cell lines in which TENT2 …

RNA uridylation is a potent and widespread posttranscriptional regulator of gene
expression. RNA uridylation has been detected in a range of eukaryotes including …