Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

To understand regulatory systems, it would be useful to uniformly determine how different
components contribute to the expression of all other genes. We therefore monitored mRNA …

Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …

Reactive oxygen species (ROS) play complex roles in aging, having both damaging effects
and signaling functions. Transiently elevating mitochondrial stress, including mitochondrial …

KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …

Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set
during each round of transcription. Central to this process is the Set2/SETD2 …

Macrophages respond to noxious stimuli and contribute to inflammatory responses by
eliminating pathogens or damaged tissue and maintaining homeostasis. Response to …

Whereas mono-, di-and trimethylation states of lysines on histones typically have specific
functions, no specific functions have been attributed so far to the different methylation states …

The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor
suppressor. Heterozygosity for defective SDH subunit genes predisposes to familial …