[HTML][HTML] The development of COVID-19 treatment
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused
a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest …
a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest …
[HTML][HTML] Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment
As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …
[HTML][HTML] Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications
Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …
Stem-like exhausted and memory CD8+ T cells in cancer
T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
[HTML][HTML] The interplay between immune and metabolic pathways in kidney disease
Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the
global population. Kidney disease encompasses a diverse group of disorders that vary in …
global population. Kidney disease encompasses a diverse group of disorders that vary in …
[HTML][HTML] Single-cell deconvolution reveals high lineage-and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
C Berlin, B Mauerer, P Cauchy… - The Journal of …, 2024 - Am Soc Clin Investig
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …
[HTML][HTML] Impact of lipid metabolism on antitumor immune response
N Mabrouk, B Lecoeur, A Bettaieb, C Paul, F Végran - Cancers, 2022 - mdpi.com
Simple Summary One of the causes of failure of anticancer therapies is the reprogramming
of lipid metabolism. Cells of innate and adaptive immunity present in the tumor …
of lipid metabolism. Cells of innate and adaptive immunity present in the tumor …
[HTML][HTML] High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses
The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
Small extracellular vesicle (sEV, or exosome) communication among cells in the tumor
microenvironment has been modeled mainly in cell culture, whereas their relevance in …
microenvironment has been modeled mainly in cell culture, whereas their relevance in …
[HTML][HTML] Unlocking potential: the role of the electron transport chain in immunometabolism
The electron transport chain (ETC) couples electron transfer with proton pumping to
generate ATP and it also regulates particular innate and adaptive immune cell function …
generate ATP and it also regulates particular innate and adaptive immune cell function …