Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells

H Zaghouani, CM Hoeman, B Adkins - Trends in immunology, 2009 - cell.com
Immunity in the newborn is characterized by minimal T helper (Th) 1 function but an excess
of Th2 activity. Since Th1 lymphocytes are important to counter microbes and Th2 cells favor …

Delayed maturation of an IL-12–producing dendritic cell subset explains the early Th2 bias in neonatal immunity

HH Lee, CM Hoeman, JC Hardaway… - The Journal of …, 2008 - rupress.org
Primary neonatal T cell responses comprise both T helper (Th) cell subsets, but Th1 cells
express high levels of interleukin 13 receptor α1 (IL-13Rα1), which heterodimerizes with IL …

[HTML][HTML] The immune response after hypoxia-ischemia in a mouse model of preterm brain injury

AM Albertsson, D Bi, L Duan, X Zhang… - Journal of …, 2014 - Springer
Background Preterm brain injury consists primarily of periventricular leukomalacia
accompanied by elements of gray-matter injury, and these injuries are associated with …

Inchoate CD8+ T cell responses in neonatal mice permit influenza-induced persistent pulmonary dysfunction

D You, M Ripple, S Balakrishna, D Troxclair… - The Journal of …, 2008 - journals.aai.org
Influenza infection remains a significant cause of pulmonary morbidity and mortality
worldwide, with the highest hospitalization and mortality rates occurring in infants and elder …

Neonatal desensitization supports long-term survival and functional integration of human embryonic stem cell-derived mesenchymal stem cells in rat joint cartilage …

S Zhang, YZ Jiang, W Zhang, L Chen… - Stem cells and …, 2013 - liebertpub.com
Immunological response hampers the investigation of human embryonic stem cells (hESCs)
or their derivates for tissue regeneration in vivo. Immunosuppression is often used after …

The neonatal adaptive immune system

DA Randolph - NeoReviews, 2005 - publications.aap.org
1. Describe the basic sequence of events that initiates an immune response. 2. Understand
the basic differences between neonatal and adult T-cell function. 3. Describe the …

Reference values of serum IgG and IgM levels in preterm and term newborns

S Alkan Ozdemir, EA Ozer, S Kose, O Ilhan… - The Journal of …, 2016 - Taylor & Francis
Aim: Although, variations of normal immunoglobulin (Ig) levels in different gestational age
and birth weight groups have been studied so far, data are still limited in newborns …

A single-step gold nanoparticle–blood serum interaction assay reveals humoral immunity development and immune status of animals from neonates to adults

T Zheng, J Crews, JL McGill, K Dhume… - ACS Infectious …, 2018 - ACS Publications
A well-developed, functional immune system is paramount to combat harmful attacks from
pathogenic organisms and prevent infectious diseases. Newborn animals and humans have …

[HTML][HTML] Возрастные особенности формирования гуморального звена иммунного ответа у детей

ЕЛ Семикина, ЕА Копыльцова… - Медицинская …, 2012 - cyberleninka.ru
Формирование гуморального иммунитета было изучено у здоровых детей: 11-ти
новорожденных, 33-х детей в возрасте 4-8 месяцев, 32-х детей в возрасте 1-2 года, 17 …

Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss–Webster mice

Y Ye, CJ Woodbury - Journal of neurophysiology, 2010 - journals.physiology.org
Cutaneous myelinated nociceptors are known to exhibit considerable heterogeneity in their
response to noxious heat. In the present experiments, we studied heat sensitivity among …