Conspectus “Drug resistance is an unavoidable consequence of the use of drugs; however,
the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor …

Fusidic acid (FA) is a natural tetracyclic triterpene isolated from fungi, which is clinically used
for systemic and local staphylococcal infections, including methicillin-resistant …

Fusidic acid (FA), a natural product fusidane triterpene-based antibiotic with unique
structural features, is active in vitro against Mycobacterium tuberculosis, the causative agent …

The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections
untreatable now and in the future. To deal with these “new challenges”, scientists tend to re …

Fusidic acid is a natural product antibiotic used clinically, primarily against staphylococcal
infections. It has also exhibited antimycobacterial activity against Mycobacterium species …

Rationale: We evaluated whether treatment outcomes for patients with multidrug-resistant
and extensively drug-resistant tuberculosis can be substantially improved when sufficient …

As the so-called “next frontier” in global economic terms, Africa's disease burden continues
to choke and cripple economic growth across the continent. The highest burden is …

Fusidic acid (FA) has previously been shown to be rapidly metabolized in rodents to its C-3
epimer, which has significantly lower antimycobacterial activity relative to FA. This was in …

Fusidic acid (FA) is a potent congener of the fusidane triterpenoid class of antibiotics.
Structure-activity relationship (SAR) studies suggest the chemical structure of FA is optimal …

Targeting translational factor proteins (TFPs) presents significant promise for the
development of innovative antitubercular drugs. Previous insights from antibiotic binding …