[HTML][HTML] Count on us: T cells in SARS-CoV-2 infection and vaccination
K Kedzierska, PG Thomas - Cell Reports Medicine, 2022 - cell.com
Robust T cell responses have been associated with milder outcomes in many infections. T
cells also establish long-term memory pools and, as they are predominantly directed toward …
cells also establish long-term memory pools and, as they are predominantly directed toward …
[HTML][HTML] Remembrance of things past: long-term B cell memory after infection and vaccination
AKE Palm, C Henry - Frontiers in immunology, 2019 - frontiersin.org
The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …
memory. The immune system can remember previously encountered pathogens, and …
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis
Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that essentially
support germinal center responses where high-affinity and long-lived humoral immunity is …
support germinal center responses where high-affinity and long-lived humoral immunity is …
[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …
[HTML][HTML] Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
dramatically expedited global vaccine development efforts,–, most targeting the viral …
dramatically expedited global vaccine development efforts,–, most targeting the viral …
[HTML][HTML] Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
I Thevarajan, THO Nguyen, M Koutsakos, J Druce… - Nature medicine, 2020 - nature.com
To the Editor—We report the kinetics of immune responses in relation to clinical and
virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) …
virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) …
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
GE Hartley, ESJ Edwards, PM Aui, N Varese… - Science …, 2020 - science.org
Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
Targeting TFH cells in human diseases and vaccination: rationale and practice
The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …
[HTML][HTML] Systems serology detects functionally distinct coronavirus antibody features in children and elderly
KJ Selva, CE Van De Sandt, MM Lemke, CY Lee… - Nature …, 2021 - nature.com
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …
[HTML][HTML] Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …