CD8 T cell activation and differentiation are tightly controlled, and dependent on the context
in which naïve T cells encounter antigen, can either result in functional memory or T cell …

According to the 'hygiene hypothesis', the decreasing incidence of infections in western
countries and more recently in developing countries is at the origin of the increasing …

Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of
psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical …

In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Type 1 diabetes develops over many years and is characterized ultimately by the destruction
of insulin-producing pancreatic beta cells by autoreactive T cells. Nonetheless, the role of …

Psoriasis is one of the most common T cell–mediated autoimmune diseases in humans.
Although a role for the innate immune system in driving the autoimmune T cell cascade has …

Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated
molecular patterns and the subsequent activation of the adaptive immune response …

Virus infections and autoimmune disease have long been linked. These infections often
precede the occurrence of inflammation in the target organ. Several mechanisms often used …