DNA sequencing by nanopore using modified nucleotides

J Ju - US Patent 8,889,348, 2014 - Google Patents
US8889348B2 - DNA sequencing by nanopore using modified nucleotides - Google Patents
US8889348B2 - DNA sequencing by nanopore using modified nucleotides - Google Patents …

Chip set-up and high-accuracy nucleic acid sequencing

R Davis, R Chen, A Bibillo, K Deierling - US Patent 9,494,554, 2016 - Google Patents
The present disclosure provides devices, systems and meth ods for sequencing nucleic acid
molecules. Nucleic acid molecules can be sequenced with a high accuracy (eg, greater than …

Systems and methods for characterizing a molecule

R Chen, R Davis - US Patent 8,324,914, 2012 - Google Patents
Techniques for characterizing a molecule are described herein. In one example, a portion of
the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore …

Method of preparation of nanopore and uses thereof

J Ju, S Kumar, C Tao, M Chien, JJ Russo… - US Patent …, 2019 - Google Patents
2013-07-24 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Nucleic acid sequencing using tags

R Davis, R Chen, A Bibillo, D Korenblum - US Patent 9,605,309, 2017 - Google Patents
This disclosure provides chips, systems and methods for sequencing a nucleic acid sample.
Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a …

Method for detecting multiple predetermined compounds in a sample

J Ju, S Kumar, C Tao, S Kalachikov… - US Patent 10,732,183, 2020 - Google Patents
This invention provides methods for detecting the presence of a plurality of predetermined
compounds in a sample using a plurality of tag moieties and at least one nanopore. This …

System for detecting electrical properties of a molecular complex

R Chen - US Patent 8,962,242, 2015 - Google Patents
A system for detecting electrical properties of a molecular complex is disclosed. The system
includes an electrode electrically coupled to a molecular complex that outputs an electrical …

Controlling translocation through nanopores with fluid wall

M Mayer, E Yusko, J Yang - US Patent 9,347,929, 2016 - Google Patents
Improved resolution and detection of nanoparticles are achieved when a nanopore
connecting liquid compartments in a device running on the Coulter principle is provided with …

Systems and methods for forming a nanopore in a lipid bilayer

R Chen, R Davis - US Patent 9,605,307, 2017 - Google Patents
Techniques for forming a nanopore in a lipid bilayer are described herein. In one example,
an agitation stimulus level Such as an electrical agitation stimulus is applied to a lipid bilayer …

Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps

RW Davis, RJA Chen - US Patent 8,845,880, 2014 - Google Patents
The present invention relates to a method of using nanopores to obtain sequence
information of sample DNAS in SS test DNAs. The method comprises using speed bumps to …