The Roles of Fatty Acids and Apolipoproteins in the Kidneys

X Pan - Metabolites, 2022 - mdpi.com
The kidneys are organs that require energy from the metabolism of fatty acids and glucose;
several studies have shown that the kidneys are metabolically active tissues with an …

Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases

C Chen, Y Shu, C Yan, H Li, Z Huang, SS Shen… - Nature …, 2024 - nature.com
Multiple sclerosis (MS) is a debilitating demyelinating disease characterized by
remyelination failure attributed to inadequate oligodendrocyte precursor cells (OPCs) …

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

J Sun, F Xie, J Wang, J Luo, T Chen, Q Jiang, Q Xi… - Microbiome, 2024 - Springer
Background Domesticated pigs serve as an ideal animal model for biomedical research and
also provide the majority of meat for human consumption in China. Porcine intramuscular fat …

Glomerular clusterin expression is increased in diabetic nephropathy and protects against oxidative stress-induced apoptosis in podocytes

J He, KL Dijkstra, K Bakker, P Bus, JA Bruijn… - Scientific Reports, 2020 - nature.com
Clusterin, a glycoprotein encoded by the CLU gene, is expressed in many tissues, including
the kidney, and clusterin expression is upregulated in the glomeruli of patients with various …

Gut Microbiota and Neonatal Acute Kidney Injury

K Yang, H He, W Dong - American Journal of Perinatology, 2024 - thieme-connect.com
Objective To characterize the relationship between gut microbiota and neonatal acute
kidney injury biomarkers based on the gut-kidney axis. Study Design The Pubmed database …

Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance

S Park, HN Cha, MG Shin, S Park, Y Kim, MS Kim… - Diabetes, 2024 - Am Diabetes Assoc
Forkhead box protein O1 (FoxO1) regulates muscle growth, but the metabolic role of FoxO1
in skeletal muscle and its mechanisms remain unclear. To explore the metabolic role of …

High serum clusterin levels are associated with premature coronary artery disease in a Chinese population

H Zhu, M Liu, T Zhai, H Pan, L Wang… - Diabetes/Metabolism …, 2019 - Wiley Online Library
Background Clusterin plays an important role in the cardiovascular system, and serum
levels of clusterin are higher in coronary artery disease patients. Here, we measured serum …

[HTML][HTML] Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer's disease

LH Chen, TSH Mak, Y Fan, DTY Ho, PC Sham… - Journal of Psychiatric …, 2020 - Elsevier
CLU encoding clusterin, has been reported to associate with Alzherimer's disease (AD) by
genome-wide association studies (GWAS) based on Caucasian populations. Our previous …

[HTML][HTML] Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis

L Liu, T Liu, R Jia, L Zhang, Z Lv, Z He, Y Qu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Hypoxia-regulated proximal tubular epithelial cells (PTCs) G2/M phase arrest/delay was
involved in production of renal tubulointerstitial fibrosis (TIF). TIF is a common pathological …

Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis

M Fukuda, H Okanishi, D Ino, K Ono, T Ota, E Wakai… - iScience, 2024 - cell.com
The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph
exhibits high potential of approximately+ 80−+ 110 mV (depending on species), which …