Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Microglia are the resident immune cells of the central nervous system (CNS) parenchyma,
which perform beneficial physiological roles across life. These immune cells actively …

Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin)
are found in the vasculature of almost all humans over 50 years of age,, making it the most …

The aggregation of medin forming aortic medial amyloid is linked to arterial wall
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …

An open question in the field is to define the mechanistic underpinning of why glymphatic
function is suppressed. Other questions include the opportunities for using glymphatic …

Medin is a principal component of localized amyloid found in the vasculature of individuals
over 50 years old. Its amyloid aggregation has been linked to endothelial dysfunction and …

The swift rise in acceptance of molecular principles defining phase separation by a broad
array of scientific disciplines is shadowed by increasing discoveries linking phase …

Brain accumulation of amyloid-beta (Aβ) is a crucial feature in Alzheimer´ s disease (AD)
and cerebral amyloid angiopathy (CAA), although the pathophysiological relationship …

Aging is a major risk factor for vascular disease. Increased levels of milk fat globule-EGF
factor 8 (MFG-E8) are associated with many age-related arterial changes, but the …

The average age of the world's elderly population is steadily increasing. This unprecedented
rise in the aged world population will increase the prevalence of age-related disorders such …