Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that exerts both
homeostatic and pathophysiological roles in the central nervous system. In pathological …

Despite the considerable progress made towards understanding ALS pathophysiology,
several key features of ALS remain unexplained, from its aetiology to its epidemiological …

Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct
evidence has been lacking due to the absence of suitable experimental models. Previously …

Background Potential biomarkers to aid diagnosis and therapy need to be identified for
Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The …

Amyotrophic lateral sclerosis (ALS) is a lethal disorder characterized by the gradual
degeneration of motor neurons in the cerebrospinal axis. Whether upper motor neuron …

We recently demonstrated that microRNA-218 (miR-218) is greatly enriched in motor
neurons and is released extracellularly in amyotrophic lateral sclerosis model rats. To …

Besides glutamate excitotoxicity, the neuroinflammatory response is emerging as a relevant
contributor to motoneuron loss in amyotrophic lateral sclerosis (ALS). In this regard, high …

Background Non-cell autonomous toxicity is one of the potential mechanisms implicated in
the etiopathogenesis of amyotrophic lateral sclerosis (ALS). However, the exact role of glial …

Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF)
induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models …

BACKGROUND AND PURPOSE Glutamate transporters play a major role in maintaining
brain homeostasis and the astrocytic transporters, EAAT1 and EAAT2, are functionally …