Noradrenergic modulation of fear conditioning and extinction
TF Giustino, S Maren - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and
memory. Here we begin with an overview of the LC-NE system. We then consider how both …
memory. Here we begin with an overview of the LC-NE system. We then consider how both …
Unrelenting fear under stress: neural circuits and mechanisms for the immediate extinction deficit
S Maren - Frontiers in Systems Neuroscience, 2022 - frontiersin.org
Therapeutic interventions for disorders of fear and anxiety rely on behavioral approaches
that reduce pathological fear memories. For example, learning that threat-predictive stimuli …
that reduce pathological fear memories. For example, learning that threat-predictive stimuli …
Norepinephrine release in the cerebellum contributes to aversive learning
The modulation of dopamine release from midbrain projections to the striatum has long
been demonstrated in reward-based learning, but the synaptic basis of aversive learning is …
been demonstrated in reward-based learning, but the synaptic basis of aversive learning is …
The neurobiology of human fear generalization: meta-analysis and working neural model
RD Webler, H Berg, K Fhong, L Tuominen… - Neuroscience & …, 2021 - Elsevier
Fear generalization to stimuli resembling a conditioned danger-cue (CS+) is a fundamental
dynamic of classical fear-conditioning. Despite the ubiquity of fear generalization in human …
dynamic of classical fear-conditioning. Despite the ubiquity of fear generalization in human …
Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in …
Fear is an emotion that serves as a driving factor in how organisms move through the world.
In this review, we discuss the current understandings of the subjective experience of fear …
In this review, we discuss the current understandings of the subjective experience of fear …
A brainstem-central amygdala circuit underlies defensive responses to learned threats
Norepinephrine (NE) plays a central role in the acquisition of aversive learning via actions in
the lateral nucleus of the amygdala (LA)[,]. However, the function of NE in expression of …
the lateral nucleus of the amygdala (LA)[,]. However, the function of NE in expression of …
Neurochemical and molecular mechanisms underlying the retrieval-extinction effect
Extinction within the reconsolidation window, or 'retrieval-extinction', has received much
research interest as a possible technique for targeting the reconsolidation of maladaptive …
research interest as a possible technique for targeting the reconsolidation of maladaptive …
Failure of fear extinction in insomnia: an evolutionary perspective
The pathophysiology of insomnia remains poorly understood, yet emerging cross-
disciplinary approaches integrating natural history, observational studies in traditional …
disciplinary approaches integrating natural history, observational studies in traditional …
Recent advances in the neurobiology of posttraumatic stress disorder: A review of possible mechanisms underlying an effective pharmacotherapy
N Malikowska-Racia, K Salat - Pharmacological Research, 2019 - Elsevier
Recent progress in the field of neurobiology supported by clinical evidence gradually
reveals the mystery of human brain functioning. So far, many psychiatric disorders have …
reveals the mystery of human brain functioning. So far, many psychiatric disorders have …
[HTML][HTML] Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
RR Wyrofsky, BAS Reyes, XY Zhang, S Bhatnagar… - Neurobiology of …, 2019 - Elsevier
The endocannabinoid (eCB) system has been implicated in a variety of physiological
functions due to abundant expression of its receptors and endogenous ligands in the central …
functions due to abundant expression of its receptors and endogenous ligands in the central …