Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance

P Stejskal, H Goodarzi, J Srovnal, M Hajdúch… - Molecular cancer, 2023 - Springer
Background Despite advances in early detection and therapies, cancer is still one of the
most common causes of death worldwide. Since each tumor is unique, there is a need to …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Release mechanisms of major DAMPs

A Murao, M Aziz, H Wang, M Brenner, P Wang - Apoptosis, 2021 - Springer
Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

H Zhou, L Zhu, J Song, G Wang, P Li, W Li, P Luo… - Molecular cancer, 2022 - Springer
Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …

[HTML][HTML] The biology, function, and applications of exosomes in cancer

J Liu, L Ren, S Li, W Li, X Zheng, Y Yang, W Fu… - … Pharmaceutica Sinica B, 2021 - Elsevier
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon
fusion of multivesicular bodies with the cell surface. They can transport nucleic acids …

The role of exosomes and their applications in cancer

Y Zhou, Y Zhang, H Gong, S Luo, Y Cui - International journal of …, 2021 - mdpi.com
Exosomes are very small extracellular vesicles secreted by multiple cell types and are
extensively distributed in various biological fluids. Recent research indicated that exosomes …

Transcriptome of extracellular vesicles: state-of-the-art

A Turchinovich, O Drapkina, A Tonevitsky - Frontiers in immunology, 2019 - frontiersin.org
Exosomes and microvesicles are two major categories of extracellular vesicles (EVs)
released by almost all cell types and are highly abundant in biological fluids. Both the …

Transfer RNAs: diversity in form and function

MD Berg, CJ Brandl - RNA biology, 2021 - Taylor & Francis
As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Diabetic nephropathy: perspective on extracellular vesicles

Y Lu, D Liu, Q Feng, Z Liu - Frontiers in Immunology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus. It is
the most frequent cause of end-stage renal disease with no definitive therapy available so …

Exosomes in sepsis

A Murao, M Brenner, M Aziz, P Wang - Frontiers in Immunology, 2020 - frontiersin.org
Sepsis is a severe state of infection with high mortality. Pathogen-associated molecular
patterns and damage-associated molecular patterns (DAMPs) initiate dysregulated systemic …